What nutrients do you need while taking a GLP-1 medication?

Women taking GLP-1 medications like semaglutide or tirzepatide should pay particular attention to vitamin D, vitamin B12, iron, folate, and magnesium, since reduced food intake can make these nutrients harder to get consistently from diet alone. Research shows nutritional deficiencies are a common, clinically relevant consequence of GLP-1 therapy, not a rare side effect. This isn't an anti-GLP-1 or pro-GLP-1 conversation; it's about what your body needs while appetite and intake change significantly.

Why nutrient gaps happen on GLP-1 medications

GLP-1 receptor agonists work partly by suppressing appetite and slowing gastric emptying, which can reduce overall food intake by up to 40% in clinical use.^[1] A retrospective study of adults using GLP-1 receptor agonists found that more than 20% developed a diagnosed nutritional deficiency within 12 months of starting the medication.^[2]

Which nutrients are most commonly affected

Vitamin D deficiency is consistently the most frequently diagnosed nutrient gap among GLP-1 users, partly because vitamin D is sequestered in fat tissue and limited sun exposure compounds the issue during weight loss.^[3] Researchers at UC Davis Health have specifically highlighted micronutrient support for B12, vitamin D, folate, magnesium, and iron as a priority area for people on GLP-1 therapies, alongside hydration strategies to counter reduced thirst signals.^[4]

"It's not a one-size-fits-all approach. Have your provider work with you."

— Dr. Jummy Amuwo, Pharm.D., MPH, BCPS, Clinical Pharmacist and Board Certified Pharmacotherapy Specialist

A broad-spectrum approach to nutrient repletion

Because GLP-1-related nutrient gaps tend to span multiple vitamins and minerals at once rather than a single deficiency, a broad-spectrum multivitamin approach is worth discussing with your provider, rather than piecing together individual supplements.

Why a comprehensive formula makes sense here

Total Prenatal, a 22-nutrient blend with ScentCert technology, was originally formulated for the high nutrient demands of pregnancy and breastfeeding, which means it already covers many of the same nutrients researchers flag as commonly depleted during GLP-1 therapy, including methylated folate, iron bisglycinate, vitamin B12, and vitamin D3.† It's third-party tested at ISO 17025 accredited labs and cGMP-certified.

Always consult your healthcare provider before starting any new supplement, especially if you are pregnant, breastfeeding, or managing a medical condition, including if you are currently taking a GLP-1 medication.

What a broad-spectrum formula does and doesn't do

Our clean-label prenatal with 5-MTHF and iron bisglycinate is not formulated specifically for GLP-1 users and is not a substitute for lab testing or provider guidance. It's one option among several for women looking for broad nutrient coverage while managing reduced food intake, and your provider may recommend a different approach based on your specific labs.

"Whatever season your body is in, whether that's pregnancy, recovery, or any kind of change, it still deserves real nourishment. That's a truth I hold onto, and it's why we build formulas meant to meet women exactly where they are."

— Amy Suzanne Upchurch, Founder and CEO of Pink Stork

Working with your provider on GLP-1 nutrition

• Ask for baseline lab testing, including vitamin D, B12, iron, calcium, and magnesium, before and periodically during GLP-1 therapy
• Prioritize protein-rich foods to help offset muscle loss that can accompany rapid weight loss
• Discuss whether a multivitamin or targeted individual supplements make more sense for your specific gaps
• Stay attentive to hydration, since reduced thirst signals are common on GLP-1 medications

For more on the muscle-specific side of this conversation, see our companion guide, how to protect muscle mass while losing weight on a GLP-1.

Frequently asked questions

Do all GLP-1 users develop nutrient deficiencies?

No, but research shows deficiencies are common. One large study found over 20% of GLP-1 users developed a diagnosed nutritional deficiency within a year, so proactive attention is worthwhile even without symptoms.

Which nutrient deficiency is most common on GLP-1 medications?

Vitamin D deficiency is the most frequently diagnosed nutrient gap reported in GLP-1 users across several studies.

Should I take a prenatal vitamin if I'm not pregnant but I'm on a GLP-1?

Some women choose a comprehensive multivitamin, including prenatal formulas, for broad nutrient coverage, but this should be discussed with your provider based on your individual labs and needs, not assumed as a default.

Can nutrient supplementation prevent muscle loss on GLP-1 medications?

Nutrient supplementation alone does not prevent muscle loss. Research points to adequate protein intake combined with resistance training as the primary strategies for preserving muscle mass during GLP-1-driven weight loss.

How often should I get labs checked while on a GLP-1?

This varies by individual and provider recommendation. Ask your provider how frequently they recommend monitoring nutrient levels while you're on GLP-1 therapy.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult your healthcare provider before starting any new supplement, especially during pregnancy, breastfeeding, or while managing a medical condition. Keep out of reach of children.